ALK upregulates POSTN and WNT signaling to drive neuroblastoma
Summary: Neuroblastoma is the most common extracranial solid tumor of childhood.While MYCN and mutant anaplastic lymphoma kinase (ALKF1174L) cooperate in tumorigenesis, how ALK contributes to tumor formation remains unclear.Here, we used a human stem cell-based model cocktail tree for sale of neuroblastoma.Mis-expression of ALKF1174L and MYCN resul